Korean Journal of Clinical Geriatrics

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2383-5699   pISSN 1229-6538

Table. 1.

Table. 1.

Effects of age on laboratory testing

Normal physiological changes with age Laboratory values that correlate
Muscle ↓Muscle mass ↓Creatinine
Bone ↓Mineral content of bone, cartilage ↑PTH (females)
↓Calcium and calcitonin
GI ↓Gastric motility, vitamin absorption, and drug absorption ↓Vitamin B12, calcium, and Fe absorption
Kidney ↓Renal function ↑Serum ANP, BNP, and GFR, creatinine ↓Renin
Immune ↓Hematopoietic stem cells, bone marrow activity, thymosin, and T-cell function ↑ANAs
↑Autoimmune antibodies
Endocrine ↑Cancer incidence ↓Aldosterone Norepinephrine
Reproductive ↓Sex hormone ↓Testosterone, estrogen, progesterone, DHEA-S, and pregnenolone

PTH, parathyroid hormone; GI, gastrointestinal; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; EPO, erythropoietin; GFR, glomerular filtration rate; ANA, antinuclear antibody; DHEA-S, sulfated dehydroepiandrosterone; GnRH, gonadotropin-releasing hormone.

Adapted from the textbook of Bishop ML et al. Clinical Chemistry 2018. p. 1702-6 [1].

Korean J Clin Geri 2022;23:73-81 https://doi.org/10.15656/kjcg.2022.23.2.73
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