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multivariate analysis for incident stroke in the patient and control groups of each inflammatory arthritis (model 2)
| Ankylosing spondylitis | Seropositive rheumatoid arthritis | Psoriatic arthritis and enteropathic spondyloarthropathy | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | ||||
| Sex |
Women | 0.66 (0.56-0.77) | <.001 | 0.66 (0.62-0.70) | <.001 | 0.64 (0.45-0.92) | 0.016 | ||
| Age |
50-59 | 3.32 (2.63-4.19) | <.001 | 2.82 (2.34-3.41) | <.001 | 4.25 (2.10-8.57) | <.001 | ||
| 60-69 | 6.78 (5.43-8.46) | <.001 | 5.31 (4.45-6.34) | <.001 | 7.85 (3.97-15.52) | <.001 | |||
| 70-79 | 10.87 (8.68-13.60) | <.001 | 10.02 (8.41-11.94) | <.001 | 10.15 (5.03-20.50) | <.001 | |||
| Subscription of health insurance |
Self-employed subscribers | 1.15 (0.99-1.34) | 0.062 | 1.07 (1.01-1.14) | 0.035 | 1.36 (0.94-1.96) | 0.100 | ||
| Medical aids recipients | 1.47 (1.09-1.99) | 0.012 | 1.37 (1.21-1.57) | <.001 | 1.14 (0.50-2.57) | 0.758 | |||
| Income level |
Quintile 4 | 0.89 (0.69-1.14) | 0.360 | 0.95 (0.85-1.05) | 0.298 | 0.94 (0.50-1.77) | 0.851 | ||
| Quintile 3 | 0.87 (0.68-1.10) | 0.239 | 0.89 (0.80-0.99) | 0.025 | 0.65 (0.34-1.26) | 0.206 | |||
| Quintile 2 | 0.82 (0.65-1.03) | 0.084 | 0.87 (0.79-0.96) | 0.004 | 0.95 (0.53-1.69) | 0.862 | |||
| Quintile 1 | 0.73 (0.59-0.92) | 0.006 | 0.82 (0.75-0.90) | <.001 | 0.83 (0.48-1.44) | 0.513 | |||
| Hypertension | 1.31 (1.11-1.55) | 0.001 | 1.10 (1.03-1.18) | 0.004 | 1.02 (0.68-1.53) | 0.936 | |||
| Diabetes mellitus | 0.94 (0.75-1.17) | 0.557 | 0.99 (0.91-1.08) | 0.869 | 0.99 (0.58-1.70) | 0.973 | |||
| Dyslipidemia | 0.93 (0.77-1.12) | 0.420 | 0.89 (0.83-0.96) | 0.003 | 0.83 (0.52-1.33) | 0.440 | |||
| Atrial fibrillation | 1.72 (1.28-2.31) | <.001 | 1.74 (1.55-1.96) | <.001 | 2.34 (1.20-4.55) | 0.012 | |||
| Diagnosis of inflammatory arthritis | 0.99 (0.80-1.22) | 0.892 | 1.11 (1.03-1.21) | 0.010 | 1.12 (0.62-2.04) | 0.706 | |||
| Use of anti-TNF agents | 0.80 (0.52-1.24) | 0.324 | 0.88 (0.69-1.12) | 0.298 | 1.49 (0.49-4.52) | 0.480 | |||
| Use of biologic agents other than anti-TNF agents | 1.56 (0.50-4.90) | 0.450 | 0.71 (0.49-1.02) | 0.067 | 1.25 (0.45-3.44) | 0.669 |
*Reference: Men, †Reference: Younger than age 50, ‡Reference: employment based subscribers, §Reference: Quintile 5.
Multivariable model was adjusted for sex, age, subscription of health insurance, income level, hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, diagnosis of inflammatory arthritis and use of anti-TNF agents, use of biologic agents other than anti-TNF agents.