Korean Journal of Geriatrics & Gerontology

Indexed in /covered by CAS, KoreaScience & DOI/Crossref:eISSN 2383-5699   pISSN 1229-6538

Table. 1.

Table. 1.

Characteristics of the included studies

Study Identification Country Intervention Subjects Sample size Mean age Duration of follow up Outcomes
Borst, 2014 [17] USA Testosterone enanthate 125 mg/week, intramuscular injections 60-year-old, hypogonadal men 30 70 years 12 months Trail making test, Benton Judgment of Line Orientation, Rey-Osterrieth Complex Figure Test, Draw from memory test
Cherrier, 2001 [20] USA Testosterone enanthate 100 mg/week, intramuscular injections Age 50 to 80 years 25 68 years 6 weeks Block Design, Story Recall, Route Test
Cherrier, 2005 [19] USA Testosterone enanthate 100 mg/week, intramuscular injections Age 50 to 90 years 41 65 years 6 weeks Route Test, Story Recall, Verbal fluency, Stroop Test, Self-Ordered Pointing Test
Cherrier, 2015 [18] USA Testosterone gel 50 to 100 mg/day, topical Age 60 to 90 years, Mild cognitive impairment 19 70 years 6 months Rey Auditory Verbal Learning Test, Story Recall, Visual Spatial Learning Test, Letter-Number Sequencing, Computerized Simple Reaction Time, Route Test, Complex Design Construction, Verbal Fluency, Mental Rotation
Emmelot-Vonk, 2008 [21] Netherlands Testosterone undecenoate, 160 mg/day, oral Age 60 to 80 years, testosterone level lower than 13.7 nmol/L 223 67 years 6 months Benton Judgment of Line Orientation, Digit Symbol Substitution, Shepard Mental Rotation, Rey Auditory Verbal Learning Test, Trail Making Test
Huang, 2016 [22] USA 7.5 g/day of 1% testosterone gel, topical 60-year-old, low-to-normal testosterone level 76 67 years 36 months Complex Figure Test, Paragraph Recall test, Buschke Selective Reminding Test, Verbal fluency test, Visual Spatial Learning Test, Stroop Interference Test, Trail Making Test
Janowsky, 1994 [24] USA testosterone Scrotal Patch (Place & Nichols, 1991; Alza, Palo Alto, CA) 15 mg/day Age 60 to 75 years 56 67 years 3 months Delayed Recall test, Visual Reproduction II test, Grooved Pegboard test, Trail Making Test, Block Design Test
Janowsky, 2000 [23] USA Testosterone enanthate 150 mg/week, intramuscular injections Age 61 to 75 years 19 67 years 1 month Stimuli and procedures for the working memory task
Kenny, 2002 [25] USA Nonscrotal testosterone patch 5 mg/day Age 61 to 75 years, bioavailable testosterone levels below 128 ng/dL 44 75 years 12 months Digit Span, Digit Symbol, Trail Making Test
Kenny, 2004 [26] USA Testosterone enanthate 200 mg every 3 weeks, intramuscular injections Early cognitive decline and bioavailable testosterone level below 128 ng/dL 11 80 years 12 weeks Dementia Rating Scale score, Folstein MMSE score, Digit Span, Verbal Fluency, Clock Face Drawing, Clock Face Perception, Trail Making Test
Lu, 2006a [27]* USA Testosterone gel (Laboratoires Besins-Iscovesco, Paris, France) 75 mg/day, topical Male patients with mild Alzheimer disease 18 69 years 24 weeks Alzheimer’s Disease Assessment Scale-Cognitive Subscale, California Verbal Learning Test, Block Design Subtest, Judgment of Line Orientation, Developmental Test of Visual Motor Integration
Lu, 2006b [27]* USA Testosterone gel (Laboratoires Besins-Iscovesco, Paris, France) 75 mg/day, topical Healthy male volunteers 29 62 years 24 weeks Alzheimer’s Disease Assessment Scale-Cognitive Subscale, California Verbal Learning Test, Block Design Subtest, Judgment of Line Orientation, Developmental Test of Visual Motor Integration
Resnick, 2017 [28] USA Testosterone gel in a pump bottle (AndroGel, AbbVie), dose was adjusted 65-year-old, with low testosterone levels 493 72 years 12 months Delayed Paragraph Recall, Benton Visual Retention Test, Card Rotation Test, Trail Making Test, Global cognitive function, Immediate Paragraph Recall
Vaughan, 2007 [29] USA Testosterone enanthate 200 mg/week, intramuscular injections 60-year-old, baseline testosterone below 350 ng/dL and no evidence of cognitive impairment 47 70 years 36 months Benton Visual Retention test, Judgment of Line Orientation test, Digit Span, Trail Making Test, Selective Reminding test, Selective Reminding test
Wahjoepramono, 2016 [30] Indonesia Testosterone cream 50 mg (AndroForte 5%) daily, topical 50-year-old, presenting with subjective memory complaints 44 61 years 24 weeks (without crossover) Mini–Mental State Examination, Rey Auditory Verbal Learning Test
Young, 2010 [31] USA Testosterone gel (Auxilium Pharmaceutical, Inc., Malvern, PA) 75 mg/day, GnRH agonist was added Age 60 to 80 years, healthy male 30 68 years 6 weeks Trail Making Test, Subject-ordered Pointing, Verbal Fluency, Paragraph Recall, Mental Rotation, Figure Discrimination

MMSE, mini–mental state examination; UK, United Kingdom; USA, United States of America.

*Lu et al. [27] presented separated group on mild Alzheimer’s disease and healthy controls and the reference is thus represented with two different studies in the table.

Korean J Clin Geri 2023;24:24-33 https://doi.org/10.15656/kjcg.2023.24.1.24
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