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Chronic Kidney Disease: A Risk Factor for Parkinson’s Disease
Korean J Clin Geri 2017 Dec;18(2):95-101
Published online December 29, 2017;  https://doi.org/10.15656/kjcg.2017.18.2.95
Copyright © 2017 The Korean Academy of Clinical Geriatrics.

Soo Jin Wang1, Jae Moon Yun1, Dong Wook Shin2, Be Long Cho1, Ki Young Son1, Sang Hyuck Kim3, Ji Eun Lee1, Soo Min Jung1, A Young Eo1, Jeong Yean Yun1

1Department of Family Medicine, Seoul National University Hospital, Seoul, 2Department of Family Medicine, Samsung Medical Center, Seoul, 3Health Screening and Promotion Center, Bundang Seoul National University Hospital, Seongnam, Korea
Received June 27, 2017; Revised August 14, 2017; Accepted August 26, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Background: This study aims to reveal risk factors of Parkinson’s disease (PD) within Chronic kidney disease (CKD) patients. A retrospective cohort was designed to clarify the association between PD and CKD through survival analysis.
Methods: Based on Korea’s National Health Insurance System (NHIS), the subjects were divided into non-CKD patients and newly diagnosed CKD patients between 2003 and 2004. From 2005 to 2013, a 9 years’ surveillance was performed to detect the occurrence of PD. The association between CKD and PD was assessed using survival analysis. Subjects were divided into 4 CKD stages based on the estimated glomerular filtration rate (eGFR): eGFR<15 (mL/min/1.73 m2), 15 to 29, 30 to 59 and 60 to 89, hazard ratios (HRs) with 95% confidence intervals (CIs) for each stages were assessed.
Results: CKD patients with an eGFR less than 15 had unadjusted HR of 2.79 (95% CI=1.25∼6.21, P<0.05) and adjusted HR of 2.60 (95% CI=1.25∼6.21, P<0.05) manifesting increased risk of PD. In male patients with eGFR less than 15, the risk was even higher in unadjusted HR of 4.21 (95% CI=1.75∼10.12, P<0.05) and adjusted HR of 3.71 (95% CI=1.54∼8.91, P<0.05). However, no significant association was found within female patients.
Conclusion: In this study, a statistically significant association between CKD and PD was found. A notable increase in risk was found in male CKD patients with eGFR less than 15. Thus CKD resulting uremia could lead to increased risk of PDs.
Keywords : Renal insufficiency, Chronic, Parkinson disease
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