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Association between Serum Carcinoembryonic Antigen Levels within Normal Range and Metabolic Syndrome in Korean Women Aged ≥50 Years Old
Korean J Clin Geri 2018 Jun;19(1):49-54
Published online June 30, 2018;  https://doi.org/10.15656/kjcg.2018.19.1.49
Copyright © 2018 The Korean Academy of Clinical Geriatrics.

Hye-Min Park, Yu-Jin Kwon, Hea-Yoon Park, Yong-Jae Lee

Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea
Received December 6, 2017; Revised February 22, 2018; Accepted March 6, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Background: The objective of this study was to investigate the relationship between serum carcinoembryonic antigen (CEA) levels and metabolic syndrome in Korean women aged ≥50 years old.
Methods: This cross-sectional study included a total of 3,479 individuals who underwent health check-ups between November 2006 and July 2010 at the Health Promotion Center of Gangnam Severance Hospital in Seoul. Serum CEA levels were categorized into quartiles: Q1 (≤1.0 µg/L), Q2 (1.1~1.4 µg/L), Q3 (1.5~2.1 µg/L), and Q4 (≥2.2 µg/L). The odds ratio (OR) and 95% confidence interval (CI) for metabolic syndrome were calculated using multiple logistic regression analysis after adjusting for confounding factors across CEA quartiles.
Results: The mean CEA levels were increased in people with obesity, high blood pressure, and high plasma glucose. Compared with the lowest CEA quartile, the OR (95% CI) for metabolic syndrome in the highest CEA quartile was 1.34 (1.03 to 1.73) after adjusting for age, cigarette smoking, alcohol intake, regular exercise, and leukocyte count.
Conclusion: CEA was significantly related with metabolic syndrome in middle aged and elderly Korean females, and elevated CEA levels may be a surrogate marker for metabolic syndrome.
Keywords : Carcinoembryonic antigen, Metabolic syndrome, Inflammation, Elderly
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June 2018, 19 (1)