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Low Concentrations of Serum Albumin May Predict Muscle Loss in Korean Adults Aged 60 Years and Older
Korean J Clin Geri 2019 Jun;20(1):10-17
Published online June 30, 2019;  https://doi.org/10.15656/kjcg.2019.20.1.10
Copyright © 2019 The Korean Academy of Clinical Geriatrics.

Soo-Hyun Lee1, Seung-Geon Park2, Ji-Eun Lee1, Hyejin Chun1, Moon-Jong Kim1, Young-Sang Kim1

1Department of Family Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea; 2Department of Family Medicine, VHS Incheon Hospital, Incheon, Korea
Received March 13, 2019; Revised April 27, 2019; Accepted May 14, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Background: The factors for predicting aging-related muscle loss are not clearly identified. The aim of this study is to examine factors associated with muscle loss in Korean older adults.
Methods: We assessed 329 subjects aged 60 years and older who participated in the health checkup programs twice in one to two years’ time period. Muscle loss group was defined as those with 5% or more decrease in fat-free mass. The biomarkers were compared between the muscle loss and non- loss groups adjusting for potential confounders.
Results: The number of subject in muscle loss group was 30 (9.1%). Serum albumin concentration was significantly lower in the muscle loss group than that in the non-loss group. Based on the ROC curve results, serum albumin was the predictor of muscle loss (Area Under Curve=0.656). Multivariate regression results presented the odds ratio of 1 standard deviation of baseline albumin level for the muscle loss was 0.446 (95% confidence intervals 0.271-0.734, P=0.001).
Conclusion: Baseline serum concentrations of albumin may be a significant indicator to predict muscle mass loss in Korean adults aged 60 years and older.
Keywords : Albumin, Korea, Muscle, Sarcopenia
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June 2019, 20 (1)