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The management of strict blood pressure was superior to non-strict group in terms of major clinical outcomes
| Chinese, Wei et al [9] | SPRINT-Senior [10] | STEP [11] | |
|---|---|---|---|
| Year | 2013 | 2016 | 2021 |
| Participants | 724 | 2,636 | 8,511 |
| Age | 76.6 (>70) | 76.6 (>75, condition to walk alone) | 66 (60-80) |
| BP criteria | SBP≥160 mmHg | SBP 160-199 mmHg | SBP 140-190 mmHg |
| Study design | Intensive (SBP≤140 mmHg) Standard (SBP 141-150 mmHg) |
Strict (SBP<120 mmHg) Moderate (SBP<140 mmHg) |
Standard 130-150 mmHg Intensive 110-130 mmHg |
| Primary outcomes | Composites of fatal/non-fatal stroke, AMI, CV death | Composite of AMI, ACS, HF, or CV death | Composite of stroke, ACS, ADHF, coronary revasc, AF, CV death |
| Follow-up | 60 months | 4 years | 3.34 years |
| Major findings | Intensive group; superior | Intensive group; superior | Intensive group; superior |
SPRINT, Systolic Blood Pressure Intervention Trial; STEP, Systolic blood pressure intervention in the elderly hypertensive patients; BP, blood pressure; SBP, systolic blood pressure; AMI, acute myocardial infarction; CV, cardiovascular; ACS, acute coronary syndrome; HF, heart failure; ADHF, acute decompensated heart failure; AF, atrial fibrillation.